SNP

Polymorphisms of PRLR and FOLR1 genes and association with milk production traits in goats

J. X. Hou, Fang, F., An, X. P., Yan, Y., Ma, T., Han, P., Meng, F. X., Song, Y. X., Wang, J. G., and Cao, B. Y., “Polymorphisms of PRLR and FOLR1 genes and association with milk production traits in goats”, vol. 13, pp. 2555-2562, 2014.

We investigated the polymorphisms of PRLR and FOLR1 genes in Xinong Saanen, Guanzhong, and Boer goat breeds by DNA sequencing and PCR–RFLP. Two novel SNPs were identified: KC109741: g.62130C>T in the 3ꞌ-UTR of goat gene PRLR, and KC136296: g.7884A>C in exon 3 of goat gene FOLR1. In the three goat breeds, the polymorphism information content was 0.20-0.27 at the g.62130C>T locus. At the g.7884A>C locus, it was 0.36 in Boer goats.

Association study of polymorphisms between the Radixin gene and rheumatoid arthritis in a Korean population

H. - K. Kim, Joo, J. - S., Lee, H. - Y., Kwon, J. - T., Sohn, D. - R., Hong, S. - J., and Kim, H. - J., “Association study of polymorphisms between the Radixin gene and rheumatoid arthritis in a Korean population”, vol. 13, pp. 3697-3703, 2014.

Radixin (RDX) is part of the ezrin-radixin-moesin (ERM) protein family. It functions as a membrane-cytoskeletal linker in actin-rich cell surface structures and is thought to be essential for cortical cytoskeleton organization, cell motility, adhesion, and proliferation. An increase in phosphorylated ERM in fibroblast-like synoviocytes contributes to rheumatoid arthritis (RA) synovial hyperplasia. We examined the genetic association between the RDX gene and RA in a Korean population.

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