SNP

Molecular cloning and characterization of KISS1 promoter and effect of KISS1 gene mutations on litter size in the goat

X. P. An, Han, P., Hou, J. X., Zhao, H. B., Yan, Y., Ma, T., Fang, F., Meng, F. X., Song, Y. X., Wang, J. G., and Cao, B. Y., Molecular cloning and characterization of KISS1 promoter and effect of KISS1 gene mutations on litter size in the goat, vol. 12, pp. 4308-4316, 2013.

Kisspeptins, the product of the KISS1 gene, play an essential role in the regulation of reproductive functions, acting primarily at the hypothalamic level of the gonadotropic axis. We detected polymorphisms of the goat KISS1 gene in 723 individuals from three goat breeds (Xinong Saanen, Guanzhong, and Boer) by DNA pooling, PCR-RFLP, and DNA sequencing methods. We cloned the promoter sequence of this gene and found it to share high similarity with that of the bovine KISS1 promoter. Six TATA boxes were found in the goat KISS1 promoter region.

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