Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro
“Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro”, vol. 14, pp. 12386-12393, 2015.,
Intervertebral disc degeneration is the main cause of lumbago disease, in which the extracellular matrix structure and moisture in the nucleus pulposus is lost continuously. In this study, we aimed to detect differential expression of silence mating type information regulation 2 homolog 1 (SIRT1) and matrix metalloproteinase-1 (MMP-1) in human intervertebral disc nucleus pulposus cells and to explore the effects of SIRT1 and MMP-1 on the development of the intervertebral disc degeneration.