Single-strand conformation polymorphism

IDH1 and IDH2 mutations in different histologic subtypes and WHO grading gliomas in a sample from Northern Brazil

I. A. Pessôa, Sagica, F. E. S., Anselmo, N. P., Brito, J. R. N., and de Oliveira, E. H. C., IDH1 and IDH2 mutations in different histologic subtypes and WHO grading gliomas in a sample from Northern Brazil, vol. 14, pp. 6533-6542, 2015.

Glioma is a term used to describe tumors derived from glial cells. These tumors are divided into subgroups based on the histological morphology and similarity of their differentiated glia cells. Traditionally, they are classified according to the World Health Organization and include astrocytomas, oligodendrogliomas, ependymomas, and oligoastrocytomas. Like most cancers, gliomas develop as a result of genetic changes that accumulate with tumor progression.

No association between FGD1 gene polymorphisms and intellectual developmental disability in the Qinba mountain area

J. L. Li, Li, Y. J., Zhang, K. J., Lan, L., Shi, J. G., Yang, X., Zhang, M. J., Zhang, F. C., and Gao, X. C., No association between FGD1 gene polymorphisms and intellectual developmental disability in the Qinba mountain area, vol. 13, pp. 127-133, 2014.

FGD1 encoding a guanine nucleotide exchange factor, specifically activates Rho GTPase cell division cycle 42 (Cdc42). Dysfunction of FGD1 causes Aarskog-Scott syndrome (MIM #305400), an X-linked disorder that may affect bone and intellectual development. However, the relationship between FGD1 and intellectual developmental disorders (IDD) remains unclear. The purpose of this study was to investigate the genetic association between the FGD1 polymorphism and IDD.

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