Single nucleotide polymorphisms

Association of c.461G>A genetic variant of OGG1 gene with pancreatic cancer susceptibility in Chinese

Z. M. Zhao, Li, C. G., Hu, M. G., Zhao, G. D., and Liu, R., Association of c.461G>A genetic variant of OGG1 gene with pancreatic cancer susceptibility in Chinese, vol. 13, pp. 7256-7261, 2014.

This study aimed to evaluate the potential association of single nucleotide polymorphisms of the 8-oxoguanine DNA glycosylase gene (OGG1) with susceptibility to pancreatic cancer (PC). A total of 764 Chinese Han subjects were recruited in this study. The polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods were used to detect the genotype of c.461G>A genetic variant of OGG1. The genotype and allele frequencies were statistically different in PC patients compared with cancer-free controls.

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