Single nucleotide polymorphism; Osteosarcoma; Vascular endothelial growth factor

Investigation of the role of VEGF gene polymorphisms in the risk of osteosarcoma

G. Zhang, Bai, R., Zhang, T., Zhang, H., Wen, S. Z., and Jiang, D. M., Investigation of the role of VEGF gene polymorphisms in the risk of osteosarcoma, vol. 14, pp. 8283-8289, 2015.

We conducted a case-control study in a Chinese population, and assessed whether the VEGF -634G/C, +936C/T, and +1612G/A polymorphisms could affect the risk of osteosarcoma and its association with environmental factors. A total of 180 consecutive osteosarcoma patients and 360 controls were included in our study. The genotypes of VEGF -634G/C, +936C/T, and +1612G/A were determined by the polymerase chain reaction-restriction fragment length polymorphism assay.

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