Single nucleotide polymorphism

Detection of novel SNPs and mapping of the fatness QTL on pig chromosome 7q1.1-1.4 region

W. H. Huang, Ma, Z. X., Xu, Z. Y., Xiong, Y. Z., and Zuo, B., “Detection of novel SNPs and mapping of the fatness QTL on pig chromosome 7q1.1-1.4 region”, vol. 10, pp. 3090-3097, 2011.

Many QTLs for fatness traits have been mapped on pig chromosome 7q1.1-1.4 in various pig resource populations. Eight novel markers, including seven SNPs and one insertion or deletion within BTNL1, COL21A1, PPARD, GLP1R, MDFI, GNMT, ABCC10, and PLA2G7 genes, as well as two previously reported SNPs in SLC39A7 and HMGA1 genes, were genotyped in Large White and Meishan pig breeds.

MRP1 polymorphisms (T2684C, C2007T, C2012T, and C2665T) are not associated with multidrug resistance in leukemic patients

F. Mahjoubi, Akbari, S., Montazeri, M., and Moshyri, F., “MRP1 polymorphisms (T2684C, C2007T, C2012T, and C2665T) are not associated with multidrug resistance in leukemic patients”, vol. 7, pp. 1369-1374, 2008.

One of the main problems in treating cancer patients is that cancer cells can develop drug resistance. Resistance to multiple anticancer drugs, so called multidrug resistance (MDR), most likely involves a nonspecific mode of resistance, through drug-efflux transporters. One of the most extensively studied genes involved in MDR is multidrug resistance protein 1 (MRP1).

Pages

Subscribe to Single nucleotide polymorphism