Single-nucleotide polymorphism

Association between macrophage migration inhibitory factor rs1007888 and GDM

Y. Zhan, Li, C., Chen, J., Yu, S., Gao, Q., Wang, Y. P., and Liu, S. G., Association between macrophage migration inhibitory factor rs1007888 and GDM, vol. 14, pp. 797-804, 2015.

We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study.

Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males

X. Y. Li, Ye, J. Z., Ding, X. P., Zhang, X. H., Ma, T. J., Zhong, R., and Ren, H. Y., Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males, vol. 14, pp. 3491-3500, 2015.

We examined the association between the methionine synthase reductase (MTRR A66G), methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), and methionine synthase (MS A2756G) genotypes and non-obstructive male infertility in a Chinese population. This case-control study included 162 infertile Chinese patients with azoospermia (N = 100) or oligoasthenozoospermia (N = 62) and 120 fertile men as controls.

Polymorphisms in the SIRT5 gene and their association with body measurement and ultrasound traits in Qinchuan cattle

L. S. Gui, Wang, H. C., Liu, G. Y., and Zan, L. S., Polymorphisms in the SIRT5 gene and their association with body measurement and ultrasound traits in Qinchuan cattle, vol. 14, pp. 3843-3853, 2015.

Silent information regulator 5 (SIRT5), a member of the Sirtuin family class III nicotinamide adenine dinucleotide-dependent protein deacetylases, plays an important role in metabolic and aging processes in mammals. We identified 4 single-nucleotide polymorphisms (SNPs) (G22010A, G22052A, G22119T, and G22245C) in the 3' untranslated regions of the SIRT5 gene from 572 Qinchuan cattle by sequencing and investigating their association with growth and ultrasound traits. The frequencies of genotype GG and allele G were high at the 4 SNPs.

Discovery of a large set of SNP and SSR genetic markers by high-throughput sequencing of pepper (Capsicum annuum)

M. Nicolaï, Pisani, C., Bouchet, J. - P., Vuylsteke, M., and Palloix, A., Discovery of a large set of SNP and SSR genetic markers by high-throughput sequencing of pepper (Capsicum annuum), vol. 11. pp. 2295-2300, 2012.

Genetic markers based on single nucleotide polymorphisms (SNPs) are in increasing demand for genome mapping and fingerprinting of breeding populations in crop plants. Recent advances in high-throughput sequencing provide the opportunity for whole-genome resequencing and identification of allelic variants by mapping the reads to a reference genome. However, for many species, such as pepper (Capsicum annuum), a reference genome sequence is not yet available. To this end, we sequenced the C. annuum cv.

Relationship between multidrug resistance 1 polymorphisms and the risk of prostate cancer in Chinese populations

F. R. Shen, Yan, C. Y., Liu, M., Feng, Y. H., and Chen, Y. G., Relationship between multidrug resistance 1 polymorphisms and the risk of prostate cancer in Chinese populations, vol. 12, pp. 3806-3812, 2013.

Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1 gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was to evaluate the association between MDR1 gene polymorphisms and the risk of prostate cancer. MDR1 gene polymorphism and its association with the risk of prostate cancer were investigated in 357 Chinese men. A novel c.1465C>T polymorphism was detected with created restriction site-polymerase chain reaction and DNA sequencing.

No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population

L. P. Sun, Ma, X. L., Liu, H. X., Wang, Y. S., and Li, X. F., No association of polymorphisms in the suppressor of cytokine signaling (SOCS)-3 with rheumatoid arthritis in the Chinese Han population, vol. 9, pp. 1518-1524, 2010.

Suppressor of cytokine signaling (SOCS)-3 is a key negative regulator of cytokine signaling that inhibits the JAK/STAT signal transduction pathway; there are reports describing its role in attenuating arthritis through SOCS-3 overexpression. We examined the relationship between polymorphisms in the coding sequence and promoter region of SOCS-3 and rheumatoid arthritis (RA) in a Chinese Han population.

Cloning, partial sequence, and single-nucleotide polymorphism of the ryanodine receptor gene of the Pacific white shrimpLitopenaeus vannamei (Penaeidae)

X. H. Chen, Zeng, D. G., and Ma, N., Cloning, partial sequence, and single-nucleotide polymorphism of the ryanodine receptor gene of the Pacific white shrimpLitopenaeus vannamei (Penaeidae), vol. 9, pp. 2406-2411, 2010.

Ryanodine receptor/calcium release channel is a large protein that plays an essential role in muscle contraction; mutations in the ryanodine receptor gene affect sensitivity to stress. As a first step towards investigating the relationship between the ryanodine receptor and shrimp cramped muscle syndrome, we cloned, partially sequenced, and examined single-nucleotide polymorphisms (SNPs) of the ryanodine receptor gene of the Pacific white shrimp (Litopenaeus vannamei). The nucleotide sequence of a 15.06-kb L.

Lack of effect of bone morphogenetic protein 2 and 4 gene polymorphisms on bone density in postmenopausal Turkish women

Z. S. Özkan, Deveci, D., E. Önalan, E., and Yüce, H., Lack of effect of bone morphogenetic protein 2 and 4 gene polymorphisms on bone density in postmenopausal Turkish women, vol. 9, pp. 2311-2316, 2010.

We investigated the effect of bone morphogenetic protein 2 and 4 (BMP-2 and -4) gene polymorphisms on bone density in postmenopausal Turkish women with osteoporosis. The frequency of single-nucleotide polymorphisms (SNPs) of BMP-2 and -4 genes was analyzed in 101 osteoporotic-postmenopausal women and 52 postmenopausal women with positive bone mineral density scores. We evaluated the frequency of the thymine→cytosine nucleotide variation at position 538 for BMP-4 and the transposition of adenine→thymine at codon 190 for BMP-2, with PCR.

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