Single nucleotide polymorphism

DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis

C. H. Liu, Tao, T., Jiang, L., Xu, B., Zhang, L., Lu, K., Zhang, X. W., Chen, S. Q., Liu, D. C., and Chen, M., DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis, vol. 14, pp. 3640-3649, 2015.

Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies have been conflicting. To clarify the role of DNMT3A polymorphisms in cancer, we conducted a meta-analysis of 2014 cases and 3089 control subjects.

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