Single nucleotide polymorphism

Cyclin D1 G870A polymorphism is associated with an increased risk of multiple myeloma

S. Wang, Huang, Y., Su, R., Fang, Z., and Han, M., Cyclin D1 G870A polymorphism is associated with an increased risk of multiple myeloma, vol. 14, pp. 5856-5861, 2015.

Cyclin D1 is an important cell cycle regulator implicated in the pathogenesis of many cancer types. In particular, translocation and overexpression of cyclin D1 are common events in multiple myeloma (MM), suggesting that it may drive the initiation and progression of this malignancy. However, the association between genetic polymorphisms of cyclin D1 and the risk for developing MM remains poorly characterized. We performed a case-control study with 67 patients with MM and 66 healthy controls in a Chinese population.

Genomic cloning, expression, and single nucleotide polymorphism association analysis of the insulin-like androgenic gland hormone gene in the oriental river prawn (Macrobrachium nipponense)

F. J. Li, Jiang, F. W., Bai, H. K., Fu, H. T., Jin, S. B., Sun, S. M., Qiao, H., and Zhang, W. Y., Genomic cloning, expression, and single nucleotide polymorphism association analysis of the insulin-like androgenic gland hormone gene in the oriental river prawn (Macrobrachium nipponense), vol. 14, pp. 5910-5921, 2015.

Increasing evidence suggests that the insulin-like andro­genic gland hormone (IAG) gene plays an important role in male sexual differentiation, metabolism, and growth in crustaceans. In the present study, we isolated the full-length genome sequence of IAG by genome walking based on the cDNA sequence in Macrobrachium nipponense. Four novel single nucleotide polymorphisms (SNPs) were studied, in­cluding 509G>T, 529G>T, 590A>T in intron 1, and 2226A>G in intron 2.

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