Single nucleotide polymorphism

Genetic variants of AICDA/CASP14 associated with childhood brain tumor

S. Jeon, Han, S., Lee, K., Choi, J., Park, S. K., Park, A. K., Ahn, H. S., Shin, H. Y., Kang, H. J., Koo, H. H., Seo, J. J., Choi, J. E., Kim, H., Ahn, Y., and Kang, D., Genetic variants of AICDA/CASP14 associated with childhood brain tumor, vol. 12, pp. 2024-2031, 2013.

We conducted a hospital-based case-control study in Korea to investigate whether apoptosis- and cell cycle control-related genes are associated with childhood brain tumor. Incident brain tumor cases (N = 70) and non-cancer controls (N = 140), frequency-matched by age and gender, were selected from 3 teaching hospitals in Seoul between 2003 and 2006. Tag single nucleotide polymorphisms (SNPs) (N = 297) in 30 genes related to apoptosis and cell cycle control were selected using a pairwise linkage-disequilibrium-based algorithm.

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