Single nucleotide polymorphism

TP53 codon 72 polymorphism in adult soft tissue sarcomas

P. S. R. Almeida, Manoel, W. J., Reis, A. A. S., Silva, E. R., Martins, E., Paiva, M. V. O., Junior, A. C. Fraga, and Saddi, V. A., TP53 codon 72 polymorphism in adult soft tissue sarcomas, vol. 7, pp. 1344-1352, 2008.

Soft tissue sarcomas (STS) are tumors of mesodermal origin, comprising about 1% of all adult neoplasms. Management of such tumors is an important medical challenge. TP53 codon 72 polymorphism results in either the arginine or proline form of the p53 protein; several studies have investigated whether codon 72 polymorphisms are risk and prognostic factors for cancer. We investigated p53 codon 72 polymorphism (Arg72Pro) frequencies with respect to the susceptibility and the clinical outcome of patients with STS.

MRP1 polymorphisms (T2684C, C2007T, C2012T, and C2665T) are not associated with multidrug resistance in leukemic patients

F. Mahjoubi, Akbari, S., Montazeri, M., and Moshyri, F., MRP1 polymorphisms (T2684C, C2007T, C2012T, and C2665T) are not associated with multidrug resistance in leukemic patients, vol. 7, pp. 1369-1374, 2008.

One of the main problems in treating cancer patients is that cancer cells can develop drug resistance. Resistance to multiple anticancer drugs, so called multidrug resistance (MDR), most likely involves a nonspecific mode of resistance, through drug-efflux transporters. One of the most extensively studied genes involved in MDR is multidrug resistance protein 1 (MRP1).

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