Single-cell gel electrophoresis

Genotoxicity testing of Ambelania occidentalis (Apocynaceae) leaf extract in vivo

L. S. Castro, Perazzo, F. F., and Maistro, E. L., Genotoxicity testing of Ambelania occidentalis (Apocynaceae) leaf extract in vivo, vol. 8, pp. 440-447, 2009.

Ambelania occidentalis is routinely used in folk medicine for treating gastrointestinal disorders, even though there have been no safety trials. We evaluated the genotoxic potential of hydro-alcoholic extracts of this plant in mice; induced DNA damage was assessed in peripheral blood leukocytes and micronucleus induction was assessed in polychromatic erythrocytes from bone marrow. The extract was administered by an oral route at single doses of 1000, 1500 and 2000 mg/kg body weight. N-nitroso-N-ethylurea was used as a positive control.

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