Sialic acid

Hemagglutinin protein of Asian strains of human influenza virus A H1N1 binds to sialic acid - a major component of human airway receptors

K. H. Chua and Chai, H. C., Hemagglutinin protein of Asian strains of human influenza virus A H1N1 binds to sialic acid - a major component of human airway receptors, vol. 11, pp. 636-643, 2012.

Hemagglutinin (HA) protein plays an important role in binding the influenza virus to infected cells and therefore mediates infection. Deposited HA sequences of 86 Asian strains of influenza A (H1N1) viruses during the first outbreak were obtained from the NCBI database and compared. Interaction of the HA protein of influenza A (H1N1) virus with the human sialic acid receptor was also studied using bioinformatics.

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