Short tandem repeat

Genetic polymorphisms of loci D18S53, D18S59, and D18S488 in fetuses from a Chinese Tianjin Han population

X. Z. Li, Liu, J., Shi, Y. F., Ju, D., Zhang, Y., Yue, T. F., Li, X. Z., Liu, J., Shi, Y. F., Ju, D., Zhang, Y., and Yue, T. F., “Genetic polymorphisms of loci D18S53, D18S59, and D18S488 in fetuses from a Chinese Tianjin Han population”, vol. 15, p. -, 2016.

We investigated the genetic polymorphisms of three short tandem repeat (STR) loci, D18S53, D18S59, and D18S488, on chromosome 18 in fetuses from a Chinese Tianjin Han population. Sixty-four villus samples and 374 amniotic fluid samples were collected from fetuses. Quantitative fluorescence polymerase chain reaction was performed to amplify the STR loci, followed by scanned electrophoresis and quantitative analysis of the fluorescence signals.

Analysis of an “off-ladder” allele at the Penta D short tandem repeat locus

Y. L. Yang, Wang, J. G., Wang, D. X., Zhang, W. Y., Liu, X. J., Cao, J., and Yang, S. L., “Analysis of an “off-ladder” allele at the Penta D short tandem repeat locus”, vol. 14, pp. 15096-15101, 2015.

Kinship testing of a father and his son from Guangxi, China, the location of the Zhuang minority people, was performed using the PowerPlex® 18D System with a short tandem repeat typing kit. The results indicated that both the father and his son had an off-ladder allele at the Penta D locus, with a genetic size larger than that of the maximal standard allelic ladder. To further identify this locus, monogenic amplification, gene cloning, and genetic sequencing were performed.

Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population

J. Dang, Peng, L., Zhong, H. J., and Huo, Z. H., “Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population”, vol. 14, pp. 10258-10266, 2015.

The androgen receptor (AR) is involved in the differentiation and growth of breast cancer. Genetic markers in the AR gene have a plausible role in modulating the risk of breast cancer. In this study, we studied the association of breast cancer and the trinucleotide repeat polymorphism (CAG)n in exon 1 of the AR gene in 202 patients with breast cancer and 183 healthy controls from our hospital (Yinchuan, China). Repeat lengths were determined by fluorescent DNA fragment analysis using the ABI GeneScan software and DNA sequencing.

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