SH2B3

Absence of SH2B3 mutation in nonobese diabetic mice

Y. J. Li, Li, X. Y., Guo, X. R., Li, Y., Shen, B. F., Shi, Y. C., and Zhang, J. Y., Absence of SH2B3 mutation in nonobese diabetic mice, vol. 11, pp. 1266-1271, 2012.

Type 1 diabetes is a chronic progressive autoimmune disease characterized by mononuclear cell infiltration, with subsequent destruction of insulin-producing β-cells. Studies have identified strong associations between type 1 diabetes and several chromosome regions, including 12q24. Association between type 1 diabetes and 12q24 arises from SNP rs3184504; rs3184504 is a nonsynonymous SNP in exon 3 of SH2B3 (also known as LNK).

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