Sevoflurane

Sevoflurane induces neurotoxicity in young mice through FAS/FASL signaling

Q. Song, Ma, Y. L., Song, J. Q., Chen, Q., Xia, G. S., Ma, J. Y., Feng, F., Fei, X. J., and Wang, Q. M., Sevoflurane induces neurotoxicity in young mice through FAS/FASL signaling, vol. 14, pp. 18059-18068, 2015.

Sevoflurane, the most widely used anesthetic in clinical practice, has been shown to induce apoptosis, inhibit neurogenesis, and cause learning and memory impairment in young mice. However, the underlying mechanism is still unknown. In this study, wild-type and the FAS- or FAS ligand (FASL)-knockout mice (age 7 days) were exposed to sevoflurane or pure oxygen. Western blotting was used to examine the expression of FAS protein.

Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis

Q. B. Yu, Li, H. M., Li, L. L., Wang, S. Y., and Wu, Y. B., Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis, vol. 14, pp. 19016-19027, 2015.

This study aimed to investigate the effect of sevoflurane on serum levels of interleukin (IL)-6 and IL-8 in patients who underwent cardiopulmonary bypass (CPB). The strength of the association between sevoflurane treatment and serum level of IL-6 and IL-8 was determined in patients who underwent CPB by summary standard mean differences (SMDs); 95% confidence interval (CI) was used.

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