Serotonin transporter

An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population

T. Tencomnao and Wongpiyabovorn, J., An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population, vol. 9, pp. 2275-2282, 2010.

The serotonin transporter (5-HTT) is of great significance in the control of the serotonergic system, and its expression is known to be upregulated in psoriasis, a chronic or recurrent inflammatory skin disease. We investigated a possible association between the 5-HTT gene-linked polymorphic region (5-HTTLPR) and psoriasis in a Thai population. One hundred and fifty-six psoriatic patients and 156 unrelated healthy controls from Bangkok were genotyped using PCR. We found no overall differences in genotype distributions or allele frequencies between the two groups.

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