Sequence variants

Association of the IFNAR1-17470 and IL-10-592 cytokine variants with susceptibility to chronic hepatitis B viral infections in a Chinese population

Y. Xiang, Huang, S. F., Xia, J. R., Ye, D. Q., Chen, P., Yang, S. S., Sun, S., Lai, X. F., and Zhang, L. P., Association of the IFNAR1-17470 and IL-10-592 cytokine variants with susceptibility to chronic hepatitis B viral infections in a Chinese population, vol. 13, pp. 9187-9195, 2014.

An association between the sequence variants of cytokine genes and various clinical outcomes in subjects infected with the hepatitis B virus (HBV) has been demonstrated. However, the results are inconsistent and inconclusive. Further studies in other populations and the evaluation of a greater number of individuals may contribute to a better understanding of the influence of the cytokine genetic variants on the evolution of HBV infections.

Sequence variants in the bovine PRDM16 gene associated with body weight in Chinese cattle breeds

J. Wang, Wang, C., Tian, R., Huang, Y. - Z., Lai, X. - S., Lan, X. - Y., Wang, J. - Q., and Chen, H., Sequence variants in the bovine PRDM16 gene associated with body weight in Chinese cattle breeds, vol. 11, pp. 746-755, 2012.

As a zinc-finger protein, PR domain containing 16 (PRDM16) controls brown fat determination by stimulating brown fat cell production while suppressing the expression of genes for production of white fat cells; mutations in this domain are associated with myelodysplastic syndrome and leukemogenesis. In our study, polymorphisms in exons 2, 3, 4, 5, 7, 8, and 9 of the PRDM16 gene were detected by PCR-SSCP, DNA sequencing and CRS-PCR-RFLP methods in 1031 cattle of the Chinese breeds: Jiaxian, Nanyang, Qinchuan, and Chinese Holstein.

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