Frequency of ANKK1, DRD2, DRD3 gene polymorphisms in refractory schizophrenia patients
, “Frequency of ANKK1, DRD2, DRD3 gene polymorphisms in refractory schizophrenia patients”, Genetics and Molecular Research, vol. 18, no. 4, 2019.
Schizophrenia
Genetic and biochemical biomarkers related to oxidative stress in patients with schizophrenia
, “Genetic and biochemical biomarkers related to oxidative stress in patients with schizophrenia”, Genetics and Molecular Research, vol. 18, no. 2, 2019.
Association between miR-137 polymorphism and risk of schizophrenia: a meta-analysis
, “Association between miR-137 polymorphism and risk of schizophrenia: a meta-analysis”, vol. 15, p. -, 2016.
miR-137, a brain-enriched microRNA, is involved in the control of neuronal proliferation, differentiation, and dendritic arborization, all of which are important for proper neurogenesis and relevant to schizophrenia. miR-137 is also known to regulate many genes implicated in schizophrenia risk. Although reports have associated the miR-137 polymorphism rs1625579 with this disease, their results have been inconsistent. The aim of this meta-analysis was to evaluate the relationship between rs1625579 and schizophrenia.
Relationship between polymorphisms in the proline dehydrogenase gene and schizophrenia risk
, “Relationship between polymorphisms in the proline dehydrogenase gene and schizophrenia risk”, vol. 14, pp. 11681-11691, 2015.
Previous studies have suggested that an association exists between the proline dehydrogenase gene (PRODH) and increased schizophrenia risk. We examined the prevalence of the PRODH 757C/T (Arg185Trp), 1766A/G (Gly521Arg), and 1852G/A (intronic mutation) polymorphisms in 175 patients with schizophrenia and 185 control subjects. All subjects were of Iranian ancestry. The PRODH 757TT, 1852AA, and 1766GG genotypes were associated with an increased risk of schizophrenia (odds ratio = 1.38, 95% confidence interval: 0.88-2.16, P = 0.001, P = 0.001, respectively).
Regulators of G-protein signaling 9 genetic variations in Chinese subjects with schizophrenia
, “Regulators of G-protein signaling 9 genetic variations in Chinese subjects with schizophrenia”, vol. 14, pp. 8458-8465, 2015.
To identify single-nucleotide polymorphisms that contribute to the genetic susceptibility to schizophrenia, we examined the potential association between schizophrenia and 9 single nucleotide polymorphisms (rs1530351, rs4791230, rs2869577, rs8077696, rs8070231, rs2292592, rs9916525, rs1122079, and rs4790953) in the G-protein signaling 9 gene. The participants included 395 schizophrenia subjects and 400 healthy controls. The selected single nucleotide polymorphisms were genotyped using mass spectrometry techniques.
Association of the VRK2 gene rs3732136 polymorphism with schizophrenia in a Northwest Chinese Han population
, “Association of the VRK2 gene rs3732136 polymorphism with schizophrenia in a Northwest Chinese Han population”, vol. 14, pp. 9404-9411, 2015.
Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations. Here, we analyzed four single nucleotide polymorphisms (SNPs) of the VRK2 gene in a total population of 893 samples, consisting of 360 patients with SCZ and 533 healthy controls of Han Chinese descent using the SNPscan method. Single SNP, haplotype, and gender-specific association analyses were performed.
