Sarcoidosis

Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk

R. Zhu, Bi, L. Q., Kong, H., Tilley, S. L., Wang, H., and Xie, W. P., “Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk”, vol. 14, pp. 3590-3600, 2015.

Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence sarcoidosis susceptibility. The strength of the association between I/D polymorphisms and sarcoidosis risk was measured based on the odds ratio and 95% confidence interval.

Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients

A. Maver, Medica, I., Salobir, B., Tercelj, M., and Peterlin, B., “Lack of association of immune-response-gene polymorphisms with susceptibility to sarcoidosis in Slovenian patients”, vol. 9, pp. 58-68, 2010.

Sarcoidosis is a chronic inflammatory disease, characterized by granulomatous inflammation, prominently involving the respiratory system. The etiology of this disease has not yet been elucidated and the contribution of genetic is not yet completely understood. We searched for novel candidate genes, utilizing a system biology approach, based on data from published transcriptional, proteomic and linkage studies of sarcoidosis.

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