S100A8

Effect of RAGE polymorphisms on susceptibility to and severity of osteoarthritis in a Han Chinese population: a case-control study

H. Y. Yang, Chuang, S. Y., Fang, W. H., Huang, G. S., Wang, C. C., Huang, Y. Y., Chu, M. Y., Lin, C., Su, W., Chen, C. Y., Yang, Y. T., and Su, S. L., Effect of RAGE polymorphisms on susceptibility to and severity of osteoarthritis in a Han Chinese population: a case-control study, vol. 14, pp. 11362-11370, 2015.

Recent studies have revealed that the inflammatory process plays a role in the pathogenesis of osteoarthritis (OA). The S100 family and receptor for advanced glycation end products (RAGE) participate in regulating inflammation, even in the production of matrix metalloproteinases (MMPs). MMP-1 degrades cartilage, which may result in OA development. Moreover, polymorphisms in RAGE, S100A8, and MMP-1 have a marked effect on ligand binding and transcription regulating.

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