rs7903146

Association between transcription factor 7-like 2 genetic polymorphisms and development of type 2 diabetes in a Chinese population

H. Y. Jia, Li, Q. Z., Lv, L. F., Jia, H. Y., Li, Q. Z., and Lv, L. F., “Association between transcription factor 7-like 2 genetic polymorphisms and development of type 2 diabetes in a Chinese population”, vol. 15, p. -, 2016.

We conducted a hospital-based case-control study to evaluate the relationship between the transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism and type 2 diabetes mellitus risk in a Chinese population. Genotyping of TCF7L2 rs7903146 was carried out using the polymerase chain reaction-restriction fragment length polymorphism method. A chi-square test revealed a statistically significant difference between the distributions of rs7903146 genotypes in type 2 diabetes mellitus patient and control groups (chi-square = 10.49, P = 0.005).

Meta-analysis of the association between the rs7903146 polymorphism at the TCF7L2 locus and type 2 diabetes mellitus susceptibility

X. H. Liu, Xie, C. G., An, Y., Zhang, X. X., and Wu, W. B., “Meta-analysis of the association between the rs7903146 polymorphism at the TCF7L2 locus and type 2 diabetes mellitus susceptibility”, vol. 14, pp. 16856-16862, 2015.

Type 2 diabetes mellitus (T2DM) is a chronic disease caused by genetic and environmental factors. T2DM has been associated with specific polymorphisms in the TCF7L2 gene. This study evaluates the relationship between the rs7903146 locus polymorphism of the TCF7L2 gene and T2DM susceptibility through meta-analysis; the overall aim is to provide a basis for evidence-based medicinal treatment of T2DM.

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