RQ-PCR

Expression profiling of CEACAM6 associated with the tumorigenesis and progression in gastric adenocarcinoma

X. Deng, Liu, P., Zhao, Y., and Wang, Q., Expression profiling of CEACAM6 associated with the tumorigenesis and progression in gastric adenocarcinoma, vol. 13, pp. 7686-7697, 2014.

Carcinoembryonic antigen-related cellular adhesion molecule 6 (CEACAM6) is a member of the immunoglobulin superfamily and has been recently reported to affect the neoplastic, metastatic, and invasive ability of malignant cells by regulating intracellular signaling pathways during tumorigenesis and progression. We investigated the expression and amplification of CEACAM6 in relation to the clinicopathological and biological significance of gastric adenocarcinoma.

Differential molecular response of the transcripts B2A2 and B3A2 to imatinib mesylate in chronic myeloid leukemia

J. Alexandre de Lemos, de Oliveira, C. Martins, Scerni, A. Carolina C., Bentes, A. Q., Beltrão, A. Cristina, Bentes, I. Regina G., Azevedo, T. Cristina, and Maradei-Pereira, L. Maria Cunh, Differential molecular response of the transcripts B2A2 and B3A2 to imatinib mesylate in chronic myeloid leukemia, vol. 4, pp. 803-811, 2005.

Chronic myeloid leukemia (CML) originates from the hematopoietic stem cell and is characterized by the reciprocal translocation t(9;22)(q34;q11), which results in the BCR-ABL fusion gene on chromosome 22q-, also known as the Philadelphia chromosome. This chimeric gene codes for a cytoplasmic protein with constitutive tyrosine-kinase activity, responsible for cellular transformation and leukemogenesis in CML.

Subscribe to RQ-PCR