Retinoblastoma

Effects of miR-26a on the expression of Beclin 1 in retinoblastoma cells

M. Li, Chen, X. M., Wang, D. M., Gan, L., Qiao, Y., Li, M., Chen, X. M., Wang, D. M., Gan, L., and Qiao, Y., “Effects of miR-26a on the expression of Beclin 1 in retinoblastoma cells”, vol. 15, p. -, 2016.

The aim of this study was to evaluate the effects of miR-26a on Beclin 1 expression in retinoblastoma (RB) cell lines (Y79 and WERi-RB-1). RB cells were transfected with miR-26a mimic, antagomir-26a, or control mimic. The Beclin 1 mRNA and protein levels were detected by quantitative polymerase chain reaction and western blot, respectively. The activity of Beclin 1 3ꞌ-UTR reporter gene was detected with the luciferase assay. After transfection with miR-26a mimic, Beclin 1 mRNA and protein levels as well as the activity of the 3'-UTR reporter gene decreased.

Identification of hub genes and pathways associated with retinoblastoma based on co-expression network analysis

Q. L. Wang, Chen, X., Zhang, M. H., Shen, Q. H., and Qin, Z. M., “Identification of hub genes and pathways associated with retinoblastoma based on co-expression network analysis”, vol. 14, pp. 16151-16161, 2015.

The objective of this paper was to identify hub genes and pathways associated with retinoblastoma using centrality analysis of the co-expression network and pathway-enrichment analysis. The co-expression network of retinoblastoma was constructed by weighted gene co-expression network analysis (WGCNA) based on differentially expressed (DE) genes, and clusters were obtained through the molecular complex detection (MCODE) algorithm. Degree centrality analysis of the co-expression network was performed to explore hub genes present in retinoblastoma.

New cytogenetic aberrations found in a case of aggressive retinoblastoma

J. E. X. S. Barros, Soares-Ventura, E. M., Santos, N., Amaral, B. A. S., Oliveira, F. M., Cruz, R. S. Vera, Morais, V. L. L., Marques-Salles, T. J., and Muniz, M. T. C., “New cytogenetic aberrations found in a case of aggressive retinoblastoma”, vol. 11. pp. 1666-1670, 2012.

We describe a case of retinoblastoma with an atypical presentation and previously unreported cytogenetic aberrations. A 19-month-old girl with left intraocular retinoblastoma was treated with enucleation and chemotherapy. The disease showed aggressive evolution within a short period between diagnosis and relapse. Eight months after diagnosis, a new large tumor was present in the orbit of the right eye, with diffuse bone pain, pancytopenia and diffuse infiltration into the bone marrow and the central nervous system. The child did not respond to treatment and died.

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