Enhancement of recombinant adeno-associated virus mediated transgene expression by targeted echo-contrast agent
“Enhancement of recombinant adeno-associated virus mediated transgene expression by targeted echo-contrast agent”, vol. 12, pp. 1318-1326, 2013.
, Ultrasound-targeted microbubble destruction (UTMD) has been recently developed for destroying bubbles carrying drugs or genes, thereby permitting local release of these target molecules. We investigated whether SonoVue®, a new contrast agent that contains phospholipid-stabilized microbubbles filled with sulfur hexafluoride vapor, is effective at delivering a recombinant adeno-associated viral (rAAV) vector to the rat heart by UTMD.