Receptor function

Functional characterization of genetic variants in the porcine TLR3 gene

L. Wang, Chen, Y. C., Zhang, D. J., Li, H. T., Liu, D., and Yang, X. Q., Functional characterization of genetic variants in the porcine TLR3 gene, vol. 13, pp. 1348-1357, 2014.

Toll-like receptor 3 (TLR3) recognizes double-stranded RNA, which is a molecular signature of viruses, and plays a pivotal role in host defense against viral invasion. Polymorphisms in the human TLR3 gene have been shown to affect the receptor function and to be associated with a variety of diseases, suggesting correlations between TLR3 polymorphisms and the disease resistance/susceptibility in pigs.

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