RANKL

MicroRNA-338-3p inhibits glucocorticoid-induced osteoclast formation through RANKL targeting

X. H. Zhang, Geng, G. L., Su, B., Liang, C. P., Wang, F., Bao, J. C., Zhang, X. H., Geng, G. L., Su, B., Liang, C. P., Wang, F., and Bao, J. C., MicroRNA-338-3p inhibits glucocorticoid-induced osteoclast formation through RANKL targeting, vol. 15, p. -, 2016.

The differentiation deficiencies of osteoclast precursors (pre-OCs) may contribute to osteoporosis. Research on osteoporosis has recently focused on microRNAs (miRNAs) that play crucial roles in pre-OC differentiation. In the current study, we aimed to analyze the expression and function of the glucocorticoid (GC)-associated miRNA-338-3p (miR-338-3p) in osteoclast formation. We found that dexamethasone induced osteoclast differentiation and inhibited miR-338-3p expression.

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