Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma
“Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma”, vol. 14, pp. 2707-2715, 2015.
, Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor prognosis and high mortality rate. In this study, we investigated the expression of Rab23 in non-tumor pancreatic tissues and PDACs via immunohistochemistry. Rab23 was found in 39 of 58 (67.2%) and in 11 of 30 (36.7%) of the PDAC and non-tumor pancreatic tissue samples (P = 0.0073), respectively. There were significant correlations between Rab23 expression and unfavorable variables, including cancer differentiation level (P = 0.0089), lymph nodal (P = 0.0099), and distant metastases (P = 0.0173).