Quercetin

Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression

L. Meng, Lv, Z., Yu, Z. Z., Xu, D., Yan, X., Meng, L., Lv, Z., Yu, Z. Z., Xu, D., and Yan, X., “Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression”, vol. 15, p. -, 2016.

This study aimed to explore the protective effect of quercetin on acute lung injury (ALI) in rats with sepsis and the related mechanism. Rats were administered different doses of quercetin intraperitoneally, and blood samples and lung tissue were collected at 24 h after treatment. Arterial blood gases, lung water content, protein content, and cell counts in bronchoalveolar lavage fluid (BALF) were measured. Morphological changes in lung tissue pathology were observed under a light microscope.

Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-κB pathway

M. Zhang, Lin, J. M., Li, X. S., Li, J., Zhang, M., Lin, J. M., Li, X. S., and Li, J., “Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-κB pathway”, vol. 15, p. -, 2016.

Quercetin, a dietary flavonoid abundant in fruits, vegetables, and herbs, presents various pharmacological effects. This study aimed to investigate the anti-inflammatory effect and the underlying mechanism of quercetin in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs). Cell viability was measured by the Cell Counting Kit-8 assay. The mRNA expression of Toll-like receptor 2 (TLR2) was assessed by quantitative real-time polymerase chain reaction.

Protective mechanism of quercetin on acute myocardial infarction in rats

B. Li, Yang, M., Liu, J. W., Yin, G. T., Li, B., Yang, M., Liu, J. W., and Yin, G. T., “Protective mechanism of quercetin on acute myocardial infarction in rats”, vol. 15, p. -, 2016.

To investigate the protective mechanism of quercetin on acute myocardial infarction (AMI) rats, an AMI rat model was established by ligating the left coronary anterior descending branch. The rats were randomly divided into the model group and low- and high-dose quercetin groups. The control group comprised sham-operated rats. The rats in the low- and high-dose quercetin groups were administered 100 and 400 mg/kg quercetin, respectively, by gavage. The rats in the control and model groups were administered isometric normal saline once daily for one week.

Rutin, quercetin, and free amino acid analysis in buckwheat (Fagopyrum) seeds from different locations

C. Z. Bai, Feng, M. L., Hao, X. L., Zhong, Q. M., Tong, L. G., and Wang, Z. H., “Rutin, quercetin, and free amino acid analysis in buckwheat (Fagopyrum) seeds from different locations”, vol. 14, pp. 19040-19048, 2015.

In this study, five common buckwheats and nine tartary buckwheats grown at different locations were analyzed for the contents of rutin, quercetin, and amino acids by high-performance liquid chromatography and spectrophotometry. The rutin content was higher than quercetin in buckwheat seeds. Rutin content was in the range from 0.05 (0.05 g per 100 g dry seeds) to 1.35% of buckwheat seeds. Quercetin content varied from 0.01 to 0.17% and in some common buckwheats it was even difficult to detect.

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