PTEN

NEDD4-1 and PTEN expression in keloid scarring

P. F. Sang, Wang, H., Wang, M., Hu, C., Zhang, J. S., Li, X. J., and Zhu, F., NEDD4-1 and PTEN expression in keloid scarring, vol. 14, pp. 13467-13475, 2015.

Keloid scarring remains a major problem in plastic surgery. The aim of this study was to determine the expression of the PTEN tumor suppressor and NEDD4-1 genes in keloid tissue and explore their effect on the formation of such scarring. Twenty keloid patients were enrolled in the study and underwent surgical removal of keloid tissue. No patient had received chemotherapy and/or radiotherapy prior to treatment. PTEN and NEDD4-1 mRNA expression was detected by reverse transcription PCR, while PTEN protein expression was assessed using immunohistochemistry.

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