Protein-protein interactions

Structural modeling and analysis of dengue-mediated inhibition of interferon signaling pathway

B. Aslam, Ahmad, J., Ali, A., Paracha, R. Z., Tareen, S. H. K., Khusro, S., Ahmad, T., Muhammad, S. A., Niazi, U., and Azevedo, V., Structural modeling and analysis of dengue-mediated inhibition of interferon signaling pathway, vol. 14, pp. 4215-4237, 2015.

Dengue virus (DENV) belongs to the family Flaviviridae and can cause major health problems worldwide, including dengue fever and dengue shock syndrome. DENV replicon in human cells inhibits interferon α and β with the help of its non-structural proteins. Non-structural protein 5 (NS5) of DENV is responsible for the proteasome-mediated degradation of signal transducer and activator of transcription (STAT) 2 protein, which has been implicated in the development of resistance against interferon-mediated antiviral effect.

Finding protein-protein interaction patterns by contact map matching

R. C. Melo, Ribeiro, C., Murray, C. S., Veloso, C. J. M., da Silveira, C. H., Neshich, G., Meira, Jr., W., Carceroni, R. L., and Santoro, M. M., Finding protein-protein interaction patterns by contact map matching, vol. 6, pp. 946-963, 2007.

We propose a novel method for defining patterns of contacts present in protein-protein complexes. A new use of the traditional contact maps (more frequently used for representation of the intra-chain contacts) is presented for analysis of inter-chain contacts. Using an algorithm based on image processing techniques, we can compare protein-protein interaction maps and also obtain a dissimilarity score between them.

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