Protein-protein interaction network

Construction of a protein-protein interaction network of Wilms’ tumor and pathway prediction of molecular complexes

W. J. Teng, Zhou, C., Liu, L. J., Cao, X. J., Zhuang, J., Liu, G. X., Sun, C. G., Teng, W. J., Zhou, C., Liu, L. J., Cao, X. J., Zhuang, J., Liu, G. X., and Sun, C. G., Construction of a protein-protein interaction network of Wilms’ tumor and pathway prediction of molecular complexes, vol. 15, p. -, 2016.

Wilms’ tumor (WT), or nephroblastoma, is the most common malignant renal cancer that affects the pediatric population. Great progress has been achieved in the treatment of WT, but it cannot be cured at present. Nonetheless, a protein-protein interaction network of WT should provide some new ideas and methods. The purpose of this study was to analyze the protein-protein interaction network of WT.

Systematic tracking of altered modules identifies disrupted pathways in teratozoospermia

Z. Q. Huang, Wang, G. X., Jiang, X. L., Tian, E. P., Yao, W. L., Zeng, T., Huang, Z. Q., Wang, G. X., Jiang, X. L., Tian, E. P., Yao, W. L., Zeng, T., Huang, Z. Q., Wang, G. X., Jiang, X. L., Tian, E. P., Yao, W. L., and Zeng, T., Systematic tracking of altered modules identifies disrupted pathways in teratozoospermia, vol. 15, p. -, 2016.

The objective of this study was to identify disrupted pathways in teratozoospermia by systematically tracking dysregulated modules in reweighted protein-protein interaction (PPI) networks. We inferred and reweighted the PPI networks of normal and teratozoospermia groups based on Spearman correlation coefficients. Modules in the PPI networks were explored via a clique-merging algorithm and altered modules were identified based on maximum weight bipartite matching.

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