Prostate cancer

Effect of IL-18 gene promoter polymorphisms on prostate cancer occurrence and prognosis in Han Chinese population

J. M. Liu, Liu, J. N., Wei, M. T., He, Y. Z., Zhou, Y., Song, X. B., Ying, B. W., and Huang, J., Effect of IL-18 gene promoter polymorphisms on prostate cancer occurrence and prognosis in Han Chinese population, vol. 12, pp. 820-829, 2013.

Interleukin-18 (IL-18) has been implicated in a wide variety of cellular functions that affect the biological response to tumors. However, there is insufficient evidence to prove that IL-18 gene variants are associated with risk of prostate cancer. We examined a possible association between two promoter polymorphisms, -137G/C (rs187238) and -607C/A (rs1946518), in the IL-18 gene and prostate cancer occurrence and prognosis in Han Chinese.

HNF1b is involved in prostate cancer risk via modulating androgenic hormone effects and coordination with other genes

Y. L. Hu, Zhong, D., Pang, F., Ning, Q. Y., Zhang, Y. Y., Li, G., Wu, J. Z., and Mo, Z. N., HNF1b is involved in prostate cancer risk via modulating androgenic hormone effects and coordination with other genes, vol. 12, pp. 1327-1335, 2013.

Prostate cancer is one of the most commonly diagnosed male malignancies. Genome wide association studies have revealed HNF1b to be a major risk gene for prostate cancer susceptibility. We examined the mechanisms of involvement of HNF1b in prostate cancer development. We integrated data from Gene Expression Omnibus prostate cancer genes from the Dragon Database of Genes Implicated in Prostate Cancer, and used meta-analysis data to generate a panel of HNF1b-associated prostate cancer risk genes.

Analysis of fusion gene expression in prostate tumors by using single-end reads

D. D. Xie, Li, J. Y., Wang, Y., Chen, L., and Yu, D. X., Analysis of fusion gene expression in prostate tumors by using single-end reads, vol. 12, pp. 2886-2894, 2013.

Fusion gene expression, a kind of chromosome rearrangement mode, has been strongly linked to prostate cancer diagnosis and prognosis as well as to the Gleason score and the American Joint Committee on Cancer stage assessment. In combination with traditional methods for locating fusion genes and scoring their association with cancer cell growth, proliferation, and invasion through the basement membrane, the emerging high-throughput sequencing technologies offer a panorama of fusion genes in a genome and facilitate the discovery of new fusion modes.

Relationship between multidrug resistance 1 polymorphisms and the risk of prostate cancer in Chinese populations

F. R. Shen, Yan, C. Y., Liu, M., Feng, Y. H., and Chen, Y. G., Relationship between multidrug resistance 1 polymorphisms and the risk of prostate cancer in Chinese populations, vol. 12, pp. 3806-3812, 2013.

Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1 gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was to evaluate the association between MDR1 gene polymorphisms and the risk of prostate cancer. MDR1 gene polymorphism and its association with the risk of prostate cancer were investigated in 357 Chinese men. A novel c.1465C>T polymorphism was detected with created restriction site-polymerase chain reaction and DNA sequencing.

Expression profile analysis reveals putative prostate cancer-related microRNAs

H. Song, Liu, Y., Pan, J., and Zhao, S. T., Expression profile analysis reveals putative prostate cancer-related microRNAs, vol. 12, pp. 4934-4943, 2013.

Annotation of prostate cancer (PC) genomes provides a foundation for discoveries that can improve the understanding and treatment of the disease. Therefore, in the present study, we used the Student t-test to identify differentially expressed PC-related mRNAs and microRNAs (miRNAs). Then, we performed interrelated mapping of miRNA target genes between abnormally expressed mRNAs and miRNAs, and explored mRNA-target miRNA interrelated pairs to explain the biological functions of miRNA during the progression of PC, thus revealing the occurrence of miRNA-mediated PC.

Meta-analysis demonstrates no association between p53 codon 72 polymorphism and prostate cancer risk

M. S. Li, Liu, J. L., Wu, Y., Wang, P., and Teng, H., Meta-analysis demonstrates no association between p53 codon 72 polymorphism and prostate cancer risk, vol. 10, pp. 2924-2933, 2011.

We examined whether p53 codon 72 polymorphism confers prostate cancer risk by conducting a meta-analysis. Two investigators independently searched the Pubmed, Embase and CBM databases. This meta-analysis was made of seven case-control studies, that included 892 prostate cancer cases and 1020 healthy controls.

Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population

Q. Qadri, Sameer, A. S., Shah, Z. A., Hamid, A., Alam, S., Manzoor, S., and Siddiqi, M. A., Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population, vol. 10, pp. 3038-3045, 2011.

Glutathione-S-transferase P1 (GSTP1) is a critical enzyme of the phase II detoxification pathway. One of the common functional polymorphisms of GSTP1 is A→G at nucleotide 313, which results in an amino acid substitution (Ile105Val) at the substrate binding site of GSTP1 and reduces catalytic activity of GSTP1.

Key pathways involved in prostate cancer based on gene set enrichment analysis and meta analysis

Q. Y. Ning, Wu, J. Z., Zang, N., Liang, J., Hu, Y. L., and Mo, Z. N., Key pathways involved in prostate cancer based on gene set enrichment analysis and meta analysis, vol. 10, pp. 3856-3887, 2011.

Prostate cancer is one of the most common male malignant neoplasms; however, its causes are not completely understood. A few recent studies have used gene expression profiling of prostate cancer to identify differentially expressed genes and possible relevant pathways. However, few studies have examined the genetic mechanics of prostate cancer at the pathway level to search for such pathways. We used gene set enrichment analysis and a meta-analysis of six independent studies after standardized microarray preprocessing, which increased concordance between these gene datasets.

A novel human G protein-coupled receptor is over-expressed in prostate cancer

R. B. Parmigiani, Magalhães, G. S., Galante, P. A. F., Manzini, C. V. B., Camargo, A. A., and Malnic, B., A novel human G protein-coupled receptor is over-expressed in prostate cancer, vol. 3, pp. 521-531, 2004.

G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the identification of a novel GPCR that shows no significant amino acid identity to any one of the known members of the GPCR superfamily.

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