Prostate cancer

Effects of siRNA-mediated silencing of Sal-like 4 expression on proliferation and apoptosis of prostate cancer C4-2 cells

K. F. Liu, Shan, Y. X., Liu, K. F., and Shan, Y. X., Effects of siRNA-mediated silencing of Sal-like 4 expression on proliferation and apoptosis of prostate cancer C4-2 cells, vol. 15, p. -, 2016.

The aim of this study was to evaluate the effects of small interfering RNA (siRNA)-inhibited expression of the Sal-like 4 (SALL4) gene on the proliferation, colony formation, and apoptosis of prostate cancer C4-2 cells. C4-2 cells were cultured and divided into a si-SALL4 group, a negative control siRNA group, and a blank control group. SALL4 mRNA levels and protein expression were detected by real-time polymerase chain reaction and western blot, respectively.

Serum levels of PSA, ALP, ICTP, and BSP in prostate cancer patients and the significance of ROC curve in the diagnosis of prostate cancer bone metastases

R. J. Wei, Li, T. Y., Yang, X. C., Jia, N., Yang, X. L., Song, H. B., Wei, R. J., Li, T. Y., Yang, X. C., Jia, N., Yang, X. L., and Song, H. B., Serum levels of PSA, ALP, ICTP, and BSP in prostate cancer patients and the significance of ROC curve in the diagnosis of prostate cancer bone metastases, vol. 15, p. -, 2016.

Bone metastasis is a common complication in prostate cancer patients that can cause bone pain and pathological fracture. This study tested serum levels of prostate specific antigen (PSA), alkaline phosphatase (ALP), bone sialoprotein (BSP), collagen type I pyridine crosslinking peptide (ICTP) in prostate cancer patients and the significance of the receiver operator characteristic (ROC) curve in the diagnosis of prostate cancer bone metastases. Eighty-three prostate cancer patients were enrolled including 42 in the bone metastases group and 41 in the non-bone metastases group.

Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer

S. Q. Zhang, Zhang, G. Q., Zhang, L., Zhang, S. Q., Zhang, G. Q., and Zhang, L., Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer, vol. 15, p. -, 2016.

Prostate cancer is a common malignant tumor in males with an unclear pathogenic mechanism. As one epigenetic regulation mechanism, DNA methylation of the whole genome and specific gene(s) plays critical roles in pathogenesis, progression, diagnosis, and treatment of prostate cancer. The E-Cadherin gene is involved in cell metabolism and has been suggested to be related with malignancy of multiple tumors. This study investigated the correlation between E-Cadherin methylation and malignancy of prostate cancer.

Effects of monomethoxypolyethylene glycol-chitosan nanoparticle-mediated dual silencing of livin and survivin genes in prostate cancer PC-3M cells

A. Q. Yang, Wang, P. J., Huang, T., Zhou, W. L., Landman, J., Yang, A. Q., Wang, P. J., Huang, T., Zhou, W. L., Landman, J., Yang, A. Q., Wang, P. J., Huang, T., Zhou, W. L., and Landman, J., Effects of monomethoxypolyethylene glycol-chitosan nanoparticle-mediated dual silencing of livin and survivin genes in prostate cancer PC-3M cells, vol. 15, p. -, 2016.

Monomethoxypolyethylene glycol-chitosan (mPEG-CS) nanoparticles were used as interfering RNA carriers to transfect human prostate cancer PC-3M cells to evaluate the effects of livin and survivin gene silencing on the proliferation and apoptosis. mPEG-CS nanoparticles with sizes of approximately 60 nm were first synthesized by ionic crosslinking. Through electrostatic adsorption, mPEG-CS-livin short hairpin RNA (shRNA), mPEG-CS-survivin shRNA, and mPEG-CS-(livin shRNA + survivin shRNA) nanoparticles were then prepared to transfect PC-3M cells.

Prediction efficiency of PITX2 DNA methylation for prostate cancer survival

Z. M. Luan, Zhang, H., Qu, X. L., Luan, Z. M., Zhang, H., Qu, X. L., Luan, Z. M., Zhang, H., and Qu, X. L., Prediction efficiency of PITX2 DNA methylation for prostate cancer survival, vol. 15, p. -, 2016.

This study determined the level of PITX2 methylation in prostate cancer and benign tissues and its relationship with the postoperative survival rate. Forty-four patients with prostate cancer who underwent radical prostatectomy and 43 patients with benign prostatic hyperplasia were selected. DNA was extracted from the tissues and PITX2 methylation status was quantitatively analyzed by using the EpiTect MethyLight method.

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