Prostate cancer

Association between the 8q24 rs6983267 T/G polymorphism and prostate cancer risk: a meta-analysis

H. S. Zhu, Zhang, J. F., Zhou, J. D., Zhang, M. J., and Hu, H. X., Association between the 8q24 rs6983267 T/G polymorphism and prostate cancer risk: a meta-analysis, vol. 14, pp. 19329-19341, 2015.

Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independently by two investigators. Pooled odds ratios (ORs) and 95% confidence intervals for 8q24 rs6983267 T/G and PCa were calculated using a fixed-effect model (the Mantel-Haenszel method).

Genetic polymorphism in sex hormone metabolism and prostate cancer risk

E. Ersekerci, Sofikerim, M., Taheri, S., Demirtas, A., and Halis, F., Genetic polymorphism in sex hormone metabolism and prostate cancer risk, vol. 14, pp. 7326-7334, 2015.

We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the study. Of these patients, 28 were diagnosed with benign prostatic hyperplasia and 32 with prostate cancer, while 30 subjects were included as a control group.

Subscribe to Prostate cancer