-174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race
“-174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race”, vol. 13, pp. 139-151, 2014.
, Interleukin-6 (IL-6), a pro-inflammatory cytokine, is involved in prostate cancer progression, including androgen independence. Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. Since circulating cytokine levels vary considerably inter-individually, such variation could be linked to genetic factors, including genetic polymorphism. The -174G>C/rs1800795 polymorphism in the IL-6 promoter is functionally relevant in terms of transcriptional regulation and disease association.