Promoter activity

Expression patterns and promoter activity analysis of UGP2 in pigs

J. Y. Yu, Shao, S. M., Chen, K., Lei, M. G., and Xiong, Y. Z., “Expression patterns and promoter activity analysis of UGP2 in pigs”, vol. 13, pp. 1358-1365, 2014.

The function of the UDP-glucose pyrophosphorylase 2 gene (UGP2) in pig is not clear. In the present study, we used RNA isolated from Large White pigs and Chinese indigenous MeiShan pigs to examine the temporal coordination of changes in gene expression within muscle tissues. We cloned both the complete genomic DNA sequence and 2077-bp 5ꞌ-flanking sequence of porcine UGP2, to determine the genomic sequence. Real-time RT-PCR revealed that UGP2 was highly expressed in liver and skeletal muscle of MeiShan pigs.

Identification of the porcine sialoadhesin gene promoter region and its cell-specific expression in porcine alveolar macrophage cells

W. Sun, Xie, Z., Zhang, S., Nan, W., and Chen, J., “Identification of the porcine sialoadhesin gene promoter region and its cell-specific expression in porcine alveolar macrophage cells”, vol. 13, pp. 9615-9621, 2014.

Porcine reproductive and respiratory syndrome (PRRS), which is caused by the PRRS virus (PRRSV), is a communicable disease. PRRS caused huge economic losses to swine breeding. The porcine alveolar macrophage (PAM) cell is the main target cell of PRRSV; therefore, it is very important to identify the specific gene promoter that controls expression in PAM cells so that the anti-PRRSV exogenous gene can be efficiently and specifically expressed in PAM cells to improve porcine resistance to PRRSV.

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