WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce “browning” of white adipocytes in mice
“WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce “browning” of white adipocytes in mice”, vol. 14, pp. 6978-6984, 2015.
, The ability of mammals to resist body fat accumulation is linked to their ability to expand the number of “brown adipocytes” within white fat depots. All-trans retinoic acid (t-RA) and peroxisome proliferator-activated receptor-α (PPARα) have been implicated in “browning-like” or “browning” programs, respectively. However, a PPARα-agonist (WY14643) failed to regulate the expression of the uncoupling protein 1(UCP1) gene unless combined with retinoic acid.