Proliferation cell nuclear antigen

Expression of hypoxia-inducible factor-1α during ovarian follicular growth and development in Sprague-Dawley rats

Z. H. Zhang, Chen, L. Y., Wang, F., Wu, Y. Q., Su, J. Q., Huang, X. H., Cheng, Y., and Wang, Z. C., Expression of hypoxia-inducible factor-1α during ovarian follicular growth and development in Sprague-Dawley rats, vol. 14, pp. 5896-5909, 2015.

Hypoxia-inducible factor-1α (HIF-1α) has been identified as a transcription factor that is involved in diverse physiological and pathological processes in the ovary. In this study, we examined whether HIF-1α is expressed in a cell- and stage-specific manner during follicular growth and development in the mammalian ovaries. Using immunohistochemistry and Western blot analysis, HIF-1α expression was observed in granulosa cells specifically and was significantly increased during the follicular growth and development of postnatal rats.

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