Proliferation

Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells

Y. Deng, Sun, J., Zhang, L. D., Deng, Y., Sun, J., and Zhang, L. D., Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells, vol. 15, p. -, 2016.

The purpose of this study was to investigate the effect of ST2825, an inhibitor of myeloid differentiation factor 88 (MyD88), on the proliferation and apoptosis of human hepatocellular carcinoma (HCC) cells as well as the potential mechanism and clinical significance of ST2825 in the treatment of HCC. Immunohistochemical staining with an MyD88 antibody was performed on tissues from 80 human HCC patients and adjacent normal tissues.

Regulatory role of microRNA184 in osteosarcoma cells

G. R. Yin, Wang, Q., Zhang, X. B., and Wang, S. J., Regulatory role of microRNA184 in osteosarcoma cells, vol. 14, pp. 14246-14252, 2015.

Osteosarcoma is a highly malignant cancer that often appears in teenagers. It is the most frequently occurring primary bone tumor, and can easily metastasize, resulting in high mortality. MicroRNAs express abnormally in osteosarcoma, and may function as oncogenes or tumor suppressors. Recent studies showed that microRNA184 (miR-184) is abnormally expressed in multiple tumors, and is involved in tumor cell growth, differentiation, invasion, and metastasis. Nevertheless, the role of miR-184 in osteosarcoma cells remains unknown.

Decreased miR-134 expression and its tumor-suppressive function in human osteosarcoma

Y. Bao, Peng, L., Ma, J., Liu, K., and Li, W., Decreased miR-134 expression and its tumor-suppressive function in human osteosarcoma, vol. 14, pp. 16771-16781, 2015.

Dysregulation of microRNA (miR) is often associated with cancer development and progression. Aberrant expression of miR-134 has been found in some types of cancer. However, its expression and function in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-134 in osteosarcoma tumorigenesis and development. The expression level of miR-134 was quantified by real-time reverse transcription-polymerase chain reaction in human osteosarcoma cell lines and tissues.

Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma

L. Q. Zhang, Sun, S. L., Li, W. Y., Feng, Z., Xu, X. Y., Zhuang, Q. S., and Fang, J., Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma, vol. 14, pp. 18315-18324, 2015.

Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The expression level of miR-874 was quantified by real-time reverse transcription-polymerase chain reaction (RT-PCR) in human osteosarcoma cell lines and tissues.

Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation

R. Wang, Zheng, J., Zhang, D. - S., Yang, Y. - H., and Zhao, Z. - F., Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation, vol. 14, pp. 7315-7325, 2015.

Osteosarcoma is one of the most common primary bone tumors in children and young adults. In this study, we investigated the role of musculoaponeurotic fibrosarcoma oncogene homolog K (MAFK) in osteosarcoma cell proliferation in vitro and the possible pathways that contributed to MAFK-related osteosarcoma development. We first reported that MAFK was expressed at low levels in an osteosarcoma cell line. Furthermore, a significant correlation between MAFK and the Wnt signaling pathway was observed in osteosarcoma by using a gene microarray assay.

Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression

Z. T. Wang, Gong, H. Y., Zheng, F., Liu, D. J., and Dong, T. L., Propofol suppresses proliferation and invasion of pancreatic cancer cells by upregulating microRNA-133a expression, vol. 14, pp. 7529-7537, 2015.

Propofol is a commonly used intravenous anesthetic. We evaluated its effects on the behavior of human pancreatic cancer cells and the underlying molecular mechanisms. The effects of propofol on Panc-1 cell proliferation, apoptosis, and invasion were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, caspase-3 activity measurement, and Matrigel invasion assay. Quantitative polymerase chain reaction (qPCR) was used to assess microRNA-133a (miR-133a) expression.

Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression

Z. T. Wang, Gong, H. Y., Zheng, F., Liu, D. J., and Yue, X. Q., Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression, vol. 14, pp. 8117-8124, 2015.

Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasion were detected by MTT assay, flow cytometric analysis, and matrigel invasion assay. Real-time polymerase chain reaction (PCR) was used to assess microRNA (miR)-221 expression.

Role of adiponectin in adipose tissue wound healing

C. E. Jin, Xiao, L., Ge, Z. H., Zhan, X. B., and Zhou, H. X., Role of adiponectin in adipose tissue wound healing, vol. 14, pp. 8883-8891, 2015.

The purpose of this study was to investigate the mechanism behind adipose tissue wound healing (ATWH). The preadipocyte cell line 3T3-L1 was cultured and expression of adiponectin receptors (AdipoR1/2) was detected by immunohistochemistry and reverse transcription polymerase chain reaction. The concentration of adiponectin secreted at different cell densities was measured by enzyme-linked immunosorbent assay, while preadipocyte proliferation and migration were determined in vitro by MTT and wound closure assays. AdipoR1/2 were found to be expressed in 3T3-L1 preadipocytes.

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