Proliferation

Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression

Z. T. Wang, Gong, H. Y., Zheng, F., Liu, D. J., and Yue, X. Q., Propofol suppresses proliferation and invasion of gastric cancer cells via downregulation of microRNA-221 expression, vol. 14, pp. 8117-8124, 2015.

Propofol is one of the extensively and commonly used intravenous anesthetic agents. The current study aimed to evaluate the effects of propofol on the behavior of human gastric cancer cells and the molecular mechanisms of this activity. The effects of propofol on SGC7901 and AGS cell proliferation, apoptosis, and invasion were detected by MTT assay, flow cytometric analysis, and matrigel invasion assay. Real-time polymerase chain reaction (PCR) was used to assess microRNA (miR)-221 expression.

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