Prognostic marker

FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma

G. T. Peterle, Santos, M., Mendes, S. O., Carvalho-Neto, P. B., Maia, L. L., Stur, E., Agostini, L. P., Silva, C. V. M., Trivilin, L. O., Nunes, F. D., Carvalho, M. B., Tajara, E. H., Louro, I. D., and Silva-Conforti, A. M. A., FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma, vol. 14, pp. 11145-11153, 2015.

Currently, the most important prognostic factor in oral squamous cell carcinoma (OSCC) is the presence of regional lymph node metastases, which correlates with a 50% reduction in life expectancy. We have previously observed that expression of hypoxia genes in the tumor inflammatory infiltrate is statistically related to prognosis in OSCC. FAS and FASL expression levels in OSCC have previously been related to patient survival.

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