Prognosis

HIF-2α as a prognostic marker for breast cancer progression and patient survival

H. X. Wang, Qin, C., Han, F. Y., Wang, X. H., and Li, N., HIF-2α as a prognostic marker for breast cancer progression and patient survival, vol. 13, pp. 2817-2826, 2014.

Malignant cells show increased invasion potency in vitro and in vivo. This process is considered to be mediated by matrix-metalloproteases (MMPs). Hypoxia-inducible factor-2α (HIF-2α) may upregulate MMP-2 expression; however, little is known about the correlation between HIF-2α and MMP-2 expressions in breast cancer. The current study investigated this correlation immunohistochemically according to various clinical and pathological features in 102 paraffin-embedded archival tissue block specimens from patients with breast cancer.

Expression of RUNX3 gene in pancreatic adenocarcinoma and its clinical significance

L. - N. Xue, Bai, F. H., Wang, X. - Y., Lin, M., Tan, Y., Yao, X. - Y., and Xu, K. - Q., Expression of RUNX3 gene in pancreatic adenocarcinoma and its clinical significance, vol. 13, pp. 3940-3946, 2014.

We investigated the clinical significance of RUNX3 gene expression in human pancreatic carcinoma. Five samples of pancreatic tissues and 30 samples of pancreatic cancer tissues and paracancerous tissues were collected. RUNX3 expression was detected by real-time PCR and immunohistochemistry. The relationships between clinicopathological findings and the expression of RUNX3 were analyzed.

High-sensitivity cardiac troponin T is a predictor of recurrent acute coronary syndrome in patients with acute myocardial infarction

S. - C. Sheng, Lu, X. - M., Kang, Y., Du, Y. - P., and Wang, G. - X., High-sensitivity cardiac troponin T is a predictor of recurrent acute coronary syndrome in patients with acute myocardial infarction, vol. 13, pp. 3819-3825, 2014.

High-sensitivity cardiac troponin T is a useful tool for diagnosing myocardial ischemia. However, its role in the prognosis of patients with acute myocardial infarction has not been studied. Here, the prognostic value of high-sensitivity cardiac troponin T for patients with acute myocardial infarction was investigated.

Predictive role of vascular endothelial growth factor polymorphisms in the survival of renal cell carcinoma patients

Y. - Q. Yang and Chen, J., Predictive role of vascular endothelial growth factor polymorphisms in the survival of renal cell carcinoma patients, vol. 13, pp. 5011-5017, 2014.

We conducted a study to investigate the possible role of the vascular endothelial growth factor (VEGF) polymorphisms -2578C/A, -1154G/A and -634C/G and clinical factors in renal cell carcinoma (RCC) prognosis in a cohort of 336 RCC cases. A total of 336 patients with RCC were recruited from PLA General Hospital between January 2004 and December 2005. All patients were followed up until December 2010, and no patient was lost to follow-up. The follow-up time of this study was 60 months. At the time of analysis, a total of 210 died during the follow-up.

Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis

T. - Y. Wang, Liu, S. - G., Zhao, B. - S., Qi, B., Qin, X. - G., and Yao, W. - J., Implications of microRNA-197 downregulated expression in esophageal cancer with poor prognosis, vol. 13, pp. 5574-5581, 2014.

The aim of this study was to investigate the significance of the microRNA miR-197 expression level in relation to clinicopathological factors and prognoses of esophageal cancer (EC). MicroRNA was extracted using the Taqman® MicroRNA Assay from 46 EC patients at the same tumor node metastasis (TNM) stage, but with different prognoses, who underwent surgery. Paracancerous normal tissues were used as controls.

Clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) in colorectal cancer: a meta-analysis

Y. Wang and Zeng, T. T., Clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) in colorectal cancer: a meta-analysis, vol. 13, pp. 7102-7112, 2014.

Growing evidence has implicated that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in a spectrum of human cancers. Several observational studies from different parts of the world have been devoted to elucidate the clinical relationship between NGAL and colorectal cancer. This meta-analysis aimed to explore the overall accuracy of NGAL detection for the diagnosis and prognosis of colorectal cancer. Based on comprehensive literature screening on Pubmed, Ovid, and CNKI databases, our screening covered all published papers until March 2013.

Magnetic resonance spectroscopic imaging of brain injury after nasopharyngeal cancer radiation in early delayed reaction

W. - S. Chen, Li, J. - J., Zhang, J. - H., Hong, L., Xing, Z. - B., Wang, F., and Li, C. - Q., Magnetic resonance spectroscopic imaging of brain injury after nasopharyngeal cancer radiation in early delayed reaction, vol. 13, pp. 6848-6854, 2014.

This study aimed to investigate the value of magnetic resonance spectroscopy (MRS) imaging in assessing nasopharyngeal carcinoma radiotherapy during the early delayed reaction period. Eighty cases of nasopharyngeal cancer treated with radiotherapy within the same period underwent MRS imaging before or after radiotherapy. Of the 80 cases, 47 underwent MRS imaging on the 3rd, 4th, 6th, and 12th months after radiotherapy. The trends of the primary metabolite concentration at different time points were monitored and compared with the corresponding data after radiotherapy.

Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma

X. Wang, Liu, M., and Zhao, C. Y., Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma, vol. 13, pp. 8002-8013, 2014.

We examined the expression of ezrin and moesin in laryngeal squamous cell carcinoma (LSCC) and their correlation with patient clinicopathological characteristics and overall survival. Immunohistochemical staining and reverse transcription-polymerase chain reaction (RT-PCR) for ezrin and moesin were applied to 60 carcinoma tissues, adjacent normal tissues, and 33 metastatic lymph nodes. Survival functions were estimated using the Kaplan-Meier method and compared by the log-rank test.

Advanced oxidation protein products as a biomarker of cutaneous lupus erythematosus complicated by nephritis: a case-control study

Z. Xie, Zhang, M., Zhao, B., Wang, Q., Li, J., Liu, Y. Y., and Chen, Y. H., Advanced oxidation protein products as a biomarker of cutaneous lupus erythematosus complicated by nephritis: a case-control study, vol. 13, pp. 9213-9219, 2014.

Oxidative stress is involved in the pathogenesis of lupus nephritis (LN). The current study investigated the significance of advanced oxidation protein products (AOPPs) as a biomarker of LN in patients with cutaneous lupus erythematosus. Ninety-two patients who initially presented with systemic lupus erythematosus were divided into the LN- and LN+ groups. Serum AOPP levels were determined, and the association between AOPP levels and LN was investigated in a case-control study.

S100A4 expression and prognosis of gastric cancer: a meta-analysis

Y. Wang, Zhou, L. - B., and Li, X. - H., S100A4 expression and prognosis of gastric cancer: a meta-analysis, vol. 13, pp. 10398-10403, 2014.

The prognostic role of S100A4 in gastric cancer is still under debate. The present meta-analysis aimed to evaluate the relationship between S10A4 levels and the prognosis of gastric cancer. We performed a meta-analysis of published studies assessing the relationship between S100A4 and gastric cancer prognosis. We used the Revman 5.0 software to perform literature retrieval, article selection, data collection, and statistical analysis. A fixed-effect model was used to pool the hazard ratio (HR) and 95% confidence intervals (95%CI).

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