Prognosis

Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer

P. Liu, Xin, F., and Ma, C. F., Clinical significance of serum miR-196a in cervical intraepithelial neoplasia and cervical cancer, vol. 14, pp. 17995-18002, 2015.

Previous studies have reported that miR-196a is upregulated in cervical cancer tissues and cell lines. However, whether serum miR-196a is increased in patients with cervical cancer or cervical intraepithelial neoplasia (CIN), and its potential clinical value remained unknown. In total, 105 cervical cancer patients, 86 CIN patients, and 50 healthy volunteers were recruited. Quantitative reverse transcription-polymerase chain reaction was performed to compare the serum levels miR-196a in all participants.

Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma

L. Q. Zhang, Sun, S. L., Li, W. Y., Feng, Z., Xu, X. Y., Zhuang, Q. S., and Fang, J., Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma, vol. 14, pp. 18315-18324, 2015.

Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The expression level of miR-874 was quantified by real-time reverse transcription-polymerase chain reaction (RT-PCR) in human osteosarcoma cell lines and tissues.

Serum Dickkopf-1 levels as a clinical and prognostic factor in patients with bladder cancer

D. K. Sun, Wang, L., Wang, J. M., and Zhang, P., Serum Dickkopf-1 levels as a clinical and prognostic factor in patients with bladder cancer, vol. 14, pp. 18181-18187, 2015.

Dickkopf-1 (DKK-1) is a secreted protein that inhibits Wnt signaling. However, the clinical significance and prognostic value of serum DKK-1 levels have not been previously investigated in bladder cancer in Chinese patients. Blood samples were taken from 94 consecutive patients diagnosed with bladder cancer and 60 healthy control subjects. Serum DKK-1 expression levels were measured by enzyme-linked immunosorbent assay according to the manufacturer’s directions.

Correlation of miR-494 expression with tumor progression and patient survival in pancreatic cancer

Y. B. Ma, Li, G. X., Hu, J. X., Liu, X., and Shi, B. M., Correlation of miR-494 expression with tumor progression and patient survival in pancreatic cancer, vol. 14, pp. 18153-18159, 2015.

MicroRNA-494 (miR-494) expression is aberrant in various types of human cancer. However, the prognostic value of miR-494 in pancreatic cancer remains unclear. The level of miR-494 expression was determined in 99 pairs of primary pancreatic cancer and their corresponding, adjacent non-tumor tissues by using quantitative reverse transcriptase polymerase chain reaction. We also analyzed the associations between miR-494 expression and clinicopathological features. The survival correlations were analyzed by using the Kaplan-Meier method and Cox proportional hazards model.

Correlation of increased MALAT1 expression with pathological features and prognosis in cancer patients: a meta-analysis

X. S. Shi, Li, J., Yang, R. H., Zhao, G. R., Zhou, H. P., Zeng, W. X., and Zhou, M., Correlation of increased MALAT1 expression with pathological features and prognosis in cancer patients: a meta-analysis, vol. 14, pp. 18808-18819, 2015.

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been identified as a potential cancer biomarker, yet the mechanism by which it influences the development of cancer remains unknown. In this study, we aimed to correlate MALAT1 expression with pathological features and prognosis in cancer patients. Several databases were searched using combinations of keywords relating to MALAT1 and cancer. After selection of relevant cohort studies according to strict criteria, a meta-analysis was conducted.

Study on the correlation between the expression of Ki67 and FasL and prognosis of cervical carcinoma

S. N. Liang, Huang, Y. J., Liu, L. L., and Liu, X., Study on the correlation between the expression of Ki67 and FasL and prognosis of cervical carcinoma, vol. 14, pp. 8634-8639, 2015.

This study aimed to investigate the correlation between the expression of Ki67 and FasL and prognosis of cervical carcinoma and to explore the biological processes and signal pathways related to cervical carcinoma. Cervical carcinoma tissue specimens from 200 patients and normal tissue specimens adjacent to lesions from 30 cases were collected in this study. Ki67 and FasL proteins in these specimens were detected by immunohistochemical methods.

Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course

F. Yang, Li, J. Y., Yin, Q. N., Yang, K., Dong, S. N., Bai, L. J., Liu, P., and Tong, X. W., Human kallikrein 5 as a novel prognostic biomarker for triple-negative breast cancer: tissue expression analysis and relationship with disease course, vol. 14, pp. 9655-9666, 2015.

The purposes of this study were to analyze the expression and distribution of human kallikrein 5 (hK5) in triple-negative breast cancer (TNBC) tissues, to establish a standard operating procedure (SOP) for its immunohistochemical assay, and to evaluate the possibility of hK5 being a prognostic biomarker for TNBC. Recombinant hK5 protein and specific antibody were prepared, and the expression and distribution of hK5 in TNBC tissues were detected using immunohistochemistry.

Correlations among copeptin, ischemia-modified albumin, and the extent of myocardial injury in patients with acute carbon monoxide poisoning

J. Li, Wang, J. S., Xie, Z. X., Wang, W. Z., Wang, L., Ma, G. Y., Li, Y. Q., and Wang, P., Correlations among copeptin, ischemia-modified albumin, and the extent of myocardial injury in patients with acute carbon monoxide poisoning, vol. 14, pp. 10384-10389, 2015.

This study evaluated the relationships among copeptin, ischemia-modified albumin (IMA), and extent of myocardial injury in patients with acute carbon monoxide poisoning (ACOP). A total of 110 patients with different degrees of ACOP were selected as the poisoning group, and 30 healthy individuals as the control group. The levels of troponin I (cTnI), IMA, and copeptin were detected. Based on the presence of complications, the patients were assigned to the complication (26 patients) or non-complication (84 patients) group.

Lack of clinical significance of the ImmuKnowTM-Cylex assay for the detection of cellular immune function in patients with renal cell carcinoma

K. Zheng, Zhang, J. P., Tan, J. M., Wu, W. Z., Yang, S. L., and Ke, D. D., Lack of clinical significance of the ImmuKnowTM-Cylex assay for the detection of cellular immune function in patients with renal cell carcinoma, vol. 14, pp. 11543-11550, 2015.

This study aimed to explore the clinical value of the CD4+ T cell ATP levels in patients with renal cell carcinoma through the application of the ImmuKnowTM-Cylex® assay. We recruited 104 patients with renal cancer who had undergone surgery at Fuzhou General Hospital from March 2009 to June 2012, and were subsequently treated by dendritic cell and cytokine-induced killer cell bio-therapy or interferon-α therapy.

Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis

S. R. Yan, Liu, Z. J., Yu, S., and Bao, Y. X., Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis, vol. 14, pp. 11573-11586, 2015.

The diagnostic and prognostic value of miR-21 has been examined for hepatocellular carcinoma (HCC), with inconsistent results. Present meta-analysis summarized the diagnostic accuracy and the predictive role for survival of miR-21 in patients with HCC. All eligible studies were searched using PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases up to October 2014. For the diagnostic meta-analysis, the indices of miR-21 in the diagnosis of HCC were pooled using bivariate random-effect approach models.

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