Primary Sjögren syndrome

FAS -670A>G promoter polymorphism is associated with soluble Fas levels in primary Sjögren’s syndrome

B. A. Treviño-Talavera, Palafox-Sánchez, C. A., Muñoz-Valle, J. F., Orozco-Barocio, G., Navarro-Hernández, R. E., M. Del Mercado, V. -, I. de la Torre, G., and Oregon-Romero, E., FAS -670A>G promoter polymorphism is associated with soluble Fas levels in primary Sjögren’s syndrome, vol. 13, pp. 4831-4838, 2014.

Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands. Soluble Fas receptor (sFas) has been suggested as a Fas-mediated apoptosis blocker that could impair clonal deletion in infiltrated autoreactive cells. The FAS -670A>G promoter polymorphism has been studied in pSS. However, a relationship between FAS -670A>G promoter polymorphism and sFas levels in pSS had not been found. We examined this relationship in 77 Mexican pSS patients and 84 healthy subjects were included.

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