Primary Sjögren’s syndrome

TNFR1-383 A˃C polymorphism association with clinical manifestations in primary Sjögren’s syndrome patients

A. L. Fletes-Rayas, Palafox-Sánchez, C. A., Muñoz-Valle, J. F., Orozco-Barocio, G., Navarro-Hernández, R. E., Oregon-Romero, E., Fletes-Rayas, A. L., Palafox-Sánchez, C. A., Muñoz-Valle, J. F., Orozco-Barocio, G., Navarro-Hernández, R. E., and Oregon-Romero, E., TNFR1-383 A˃C polymorphism association with clinical manifestations in primary Sjögren’s syndrome patients, vol. 15, p. -, 2016.

Primary Sjögren’s syndrome is an autoimmune disease affecting the function of exocrine glands. Tumor necrosis factor receptor-1 (TNFR1) is involved in apoptosis through extrinsic pathway initiation. The level of soluble TNFR1 is reported increased in rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren’s syndrome patients. The TNFR1 gene contains a polymorphism that replaced an adenine with a cytosine at the -383 in promoter region position. The TNFR1-383 A˃C polymorphism has been associated with rheumatic diseases.

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