TNFR1-383 A˃C polymorphism association with clinical manifestations in primary Sjögren’s syndrome patients
, “TNFR1-383 A˃C polymorphism association with clinical manifestations in primary Sjögren’s syndrome patients”, vol. 15, p. -, 2016.
Primary Sjögren’s syndrome is an autoimmune disease affecting the function of exocrine glands. Tumor necrosis factor receptor-1 (TNFR1) is involved in apoptosis through extrinsic pathway initiation. The level of soluble TNFR1 is reported increased in rheumatoid arthritis, systemic lupus erythematosus, and primary Sjögren’s syndrome patients. The TNFR1 gene contains a polymorphism that replaced an adenine with a cytosine at the -383 in promoter region position. The TNFR1-383 A˃C polymorphism has been associated with rheumatic diseases.
