Primary biliary cirrhosis risk

Relationship between vitamin D (1,25-dihydroxyvitamin D3) receptor gene polymorphisms and primary biliary cirrhosis risk: a meta-analysis

F. Fang, Wang, J., Pan, J., Su, G. H., Xu, L. X., and Li, G., Relationship between vitamin D (1,25-dihydroxyvitamin D3) receptor gene polymorphisms and primary biliary cirrhosis risk: a meta-analysis, vol. 14, pp. 981-988, 2015.

The vitamin D (1,25-dihydroxyvitamin D3) receptor (VDR) gene encodes a protein that functions in the transcriptional regulation of vitamin D-responsive genes and plays a role in innate immunity and adaptive immune responses. In this study, we investigated the relationship between VDR polymorphisms (BsmI, ApaI, and TaqI) and primary biliary cirrhosis (PBC) risk. We conducted an overall meta-analysis and subgroup meta-analysis based on ethnicity that included a total of 6 eligible studies (672 cases and 1148 controls).

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