Pregnancy hypertension

Correlation between MTHFR gene methylation and pre-eclampsia, and its clinical significance

J. Ge, Wang, J., Zhang, F., Diao, B., Song, Z. F., Shan, L. L., Wang, W., Cao, H. J., and Li, X. Q., Correlation between MTHFR gene methylation and pre-eclampsia, and its clinical significance, vol. 14, pp. 8021-8028, 2015.

We investigated the correlation between 5,10-methy­lenetetrahydrofolate reductase (MTHFR) gene methylation and pre-eclampsia, and its clinical significance, by comparing methylation in the MTHFR gene promoter of the placenta and peripheral venous blood in pre-eclampsia and normal gravidas. We enrolled 259 gravidas from the People’s Liberation Army 202nd Hospital, China, between January 2011 and September 2011, including 127 pre-eclampsia and 132 nor­mal gravidas.

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