Predisposing genes

Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer

L. Han, Husaiyin, S., Wang, L., Wusainahong, K. D., Fu, X., and Niyazi, M., Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer, vol. 14, pp. 17252-17261, 2015.

In Uyghur women, mortality rates from cervical cancer are amongst the highest in the nation, and genetic susceptibility probably plays a role in the pathogenesis of the disease. We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women. Cervix tissue samples from 80 cases of cervical cancer and 80 cases of cervicitis were genotyped using polymerase chain reaction-sequence-based typing (PCR-SBT) for HLA-DQB1. Two hundred and ninety-six alleles were identified among the 160 cases.

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